A female builds up a lot of hormones toget ready to raise a litter and they were taken away from her, which is tough for a female with good instincts, you easily mess up a female doing that. I have seen similar things before. They are not the same after for a long time homonally and some would even say emotionally.
i would have to agree with the emotionally part. she was very sad looking and whined a lot for about a week after the pups were gone.
she actually did pretty good today. she winded hogs 3 times from the rhino but only wanted to hunt if she smelled something. other than that she stayed close