Yes, bobcat's make a huge call compared to their body size, I feel most people mistake the scream for a cougar more than not.
I've been in a stand, waitin' on deer, and heard that call... only to have a 30# bobcat come walking out when I thought it should be a lion
I've never heard a true cougar, but I would imagine I would know it wasn't a bobcat for sure. That's a relatively big animal, and your "cave man instinct" would be sure to kick in