Son- Mother cross.....
Wouldn't worry about defects unless the line has been inbred or heavily linebred for awhile.
Main thing to consider is the dogs to be crossed....
If you are wanting to reproduce common traits the two dogs you have...best way to give it a whirl.
But it also enhances the bad traits.
Better look at the so called skeletons in the dogs backgrounds ...including the male pups sire, but extremely close on the gyp..That's the one your gonna get a heavy shot of...good and bad.
Weigh the findings and Sling em....or Ring em.
Good luck
we have discussed this one quite a bit...more than like most are taking a break from this topic...

but YBM is right...and the other half to what he said is make sure to select the very best from this cross to carry on... otherwise why even do it...selecting the very best offspring is the way to eliminate and/or minimize the undesirable genes...