Ain’t going to hurt a thing, not all families and strains of dogs breed alike certain crosses work for some and may not click with others...
^ This is the truth right here. Just like some families of dogs can take a lot more inbreeding then other families. The only way to find out is to make the breeding and see.
The most important thing imo is are both dogs of breeding quality? If in your opinion they are and they are what you want more of then make that breeding.
The last thing I would recommend is keep all of the puppies or if you can't keep them all, try to keep'em close to you so you can truly see how the breeding produced. Hunt them all hard and cull harder.
Good luck!