One thing to keep in mind on linebreeding is there are things that happen that you don't see. I had a gyp that was brother/sister for 2 generations and her immune system was very weak. They couldn't count titers in her bloodwork. She died at 7. I am a believer in linebreeding but I am a firm believer in an outcross once in a while. As others have said you also can get smaller litters smaller dogs and immune system issues. I don't believe that you are anywhere near that Mike.
It's looking like Mother Nature intervened and she never got bred, I mounted my male to her once and he missed his shot and knotted up outside, so I put him in his chain and just put him in the pen the next day and left them for the rest of heat, she should be springing hard now but isn't showing any signs of it, I guess they knew something I didn't, the sire to these two is HEAVY line bred to begin with, should've went with my gut instead of logic and bred her to my Smutt male this time like I had planned on her next litter...