ivromectin wormer, cause hardening of liver?

[HYPA KENNELS]

Ivomec does not repel or keep ticks from attaching to dogs. There are no properties in Ivomec that work against ticks, nor fleas for that matter. Years and years, myself and others around me have given Ivomec once a month as a heartworm preventative, but it does not repel or kill fleas and ticks, that I know for sure. I've heard a couple folks here and there that are under that misconception, but it is indeed

Sorry but I respectfully disagree.

[halfbreed]

  so as myself this is just one study done in india i'll find the other one done in England  .

       Effect of ivermectin on the brown dog tick, Rhipicephalus sanguineus.

Morsy TA, Haridy FM.


Source

Department of Parasitology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.


Abstract


Ivermectin (Ivomec) proved to be effective in controlling R. sanguineus. All brown dog ticks infesting the treated dogs (subcutaneous injections) with 1.5 ml or 2 ml/50 kg dropped off within 4 or 3 days respectively. The dropped off ticks were completely inactive and died within one day or two. Ticks exposed to filter papers impregnated with 100 micrograms/ml (66.67%) died within four days. A dose of 1.5-2 microliters/50 kg eradicated Toxocara canis infection in four dogs, and caused shrinkage of Dipylidium caninum gravid segments in three. A general discussion was given with special reference to the contraindications and side effects of ivermectin particularly for human usage.


PMID: 10786024  [PubMed - indexed for MEDLINE]

[halfbreed]

   the brazil study 


  MATERIALS AND METHODS

All experimental work was carried out at the Bambui Research Centre of the Oswaldo Cruz Foundation, Brazil, where a research concerning the effects of reinfection on the pathology of T. cruzi infection in dogs was conducted. The dogs were young mongrels, maintained in the Centre kennels since birth. They were infected and re-infected with two different Brazilian strains of T. cruzi, being all the details pertaining to the experimental design and parasite behaviour and strain characteristics presented and discussed formerly (Machado et al. 2001). During a sudden infestation of R. sanguineus in the kennels, affecting all the animals, it became necessary to treat them in order to avoid anaemia and skin infections, as well as to prevent possible interference of tick infestation on the course of the experiments. For this, all the dogs were treated with subcutaneous injections of ivermectin (Detomax ®) at 20 mg a.i./kg. Ivermectin is the 22,23-dihydro derivative of avermectin B1, a macrocyclic lactone produced by the actinomycete Streptomyces avermitilis, which is active against a wide variety of nematode and arthropod parasites (Campbell et al. 1983, Azambuja et al. 1985, Campbell 1985, Rey 1991, Cimermann & Cimermann 1999, Barbosa & Campos 2001, PAHO 2001). The present data are a product of a casual situation, in which some dogs experimentally infected with T. cruzi became infested by R. sanguineus, so providing the opportunity to observe the possibility of a natural infection of ticks by that flagellate, as well as the eventual action of ivermectin against triatomines and trypanosomes. For this reason the experimental design of the work involves natural limitations, certainly being possible and desirable further investigations.

Fourteen young dogs with a high degree of R. sanguineus infestation were included in the present observations. Group I involved six dogs in the chronic phase of infection with both T. cruzi strains; Group II involved six dogs in the acute phase of infection; Group III involved two dogs uninfected with T. cruzi.

R. sanguineus was determined by the authors and confirmed by staff of the Zoology Department of the Federal University of Minas Gerais. To measure the infection rate of R. sanguineus by T. cruzi before the treatment with ivermectin, five fully engorged ticks were collected from each dog. Their digestive tract content was examined both by direct microscopy at 400 times (100 examined fields) and after cultivation in LIT/NNN medium (30 and 60 days of culture at 28 °C, considering two tubes for each examined tick). Pre- and post-treatment parasitaemia in the dogs was assessed by daily examination of fresh blood films (Brener 1961, Machado et al. 2001) for a period of 30 days post ivermectin treatment. Xenodiagnosis of each dog was also carried out at 13 days post-treatment using 20 laboratory-reared 4th instar nymphs of Triatoma infestans. The faecal material of these bugs was microscopically examined after 30, 60, and 90 days, after which negative bugs were dissected for examination of their entire digestive tract content.

To assess the effect of the ivermectin treatment on feeding triatomine bugs, a xenodiagnosis box containing five 4th instar nymphs of T. infestans was applied for 30 min to each of the dogs at intervals of 24, 72, 144, and 312 h after ivermectin treatment. These bugs were then maintained individually and offered a weekly feed on white mice, in order to assess their subsequent survivorship over the following 35 days. To compare the effects on different triatomine species, ten 4th instar nymphs of T. infestans and ten 4th instar nymphs of Rhodnius neglectus were allowed to feed from the same dog 24h after ivermectin treatment. These bugs were then maintained for 35 days, with a bloodfeed on chicken offered after 15days, in order to assess subsequent survivorship.

 

RESULTS

Action of ivermectin against tick infestation - The ivermectin treatment appeared to be highly effective against R. sanguineus, leading to complete elimination of all signs of tick infestation of the dogs within one week of treatment. Two months later, however, some tick reinfestation was noted presumably due to ticks hiding within the structure of the kennels. Accordingly, ivermectin treatment was repeated, but accompanied also by residual spraying of the kennels themselves with deltamethrin SC (25 mg a.i./m2 ). No ticks have been found since then, either on the dogs or within the kennel structure. There were no discernable side-effects of ivermectin treatment on the dogs, confirming previously reported studies (Barbosa & Campos 2001, Campbell 1985).

Parasitism of ticks by T. cruzi - No evidence of T. cruzi infection was found amongst ticks collected from chronically infected dogs (Group I). However, one of 37 ticks collected from dogs in the acute stage of T. cruzi infection (Group II) showed by microscopy a sparse infection of flagellates. LIT/NNN cultures from these ticks showed no flagellates at 30 days, but one culture from 27 of 37 ticks (73%) showed positive at 60 days (Table I).

Influence of ivermectin on T. cruzi infection in dogs - Considering the opportunistic character of this observation, in spite of the natural limitations in terms of technical approach, no apparent influence of ivermectin treatment was discernible on T. cruzi parasitaemia in the infected dogs. All treated dogs in the acute phase of infection (Group II) presented detectable parasitaemia by direct blood film examination during the first three weeks of infection, with similar levels of parasitaemia to those observed in untreated dogs during other periods of the long-term study (see Machado et al. 2001). In our experience, dogs in the chronic phase of T. cruzi infection never present detectable parasitaemia by direct examination, and this was unchanged by the ivermectin treatment. Similarly, xenodiagnosis of chronically infected dogs did not reveal T. cruzi infection, either in ivermectin treated animals or in previously studied untreated animals (Table II).



 

[HYPA KENNELS]

Thanks for that post I have never had a flea and tick problem in my kennels and I use ivomectin religiously.  I also do NOT spray or bath my hounds .
Be it may they are still shiny coated healthy and worm, tick, and flea free.

You also CAN use ivomectin on dogs younger than 6 months old to rid Gastric worms but the only worm it dosnt effect is tape. Wd here use the cannondon wormer for the tape.

[halfbreed]

  yes I start my pups on ivomect @ 12 weeks of age and I have on occasion started them sooner when I was out of their regular wormer  . I have gone back thru many studies on the side effects of ivomectin and have yet to find one that confirms hardening of the liver .

[MrsLouisianaHogDog]

Interesting reads. Thank you for sharing.

Well, all I know is what I've learned in my studies over the years in veterinary medicine, and, I personally have used, along with others I know, Ivomec orally once a month in my dogs for years and years, and we still pick up ticks when hunting, and we still have minor flea issues certain times a year. I sure do WISH that the Ivomec would kill and or repel fleas, and ticks, for us........

I am not discrediting anything you're saying HYPA Kennels, I am just going off of what medical knowledge I posses along with the years of personal experience I have had using Ivomec. I'm no expert by ANY means. 

[HYPA KENNELS]

I would love for them to make something to keep the flies away that wouldn't be so harmful to dogs and family members lord knows the dogs would be happy!
I too during hot summers when the grass around the kennels kinda go grey I will spot a tick or 2 in the kennels and even fleas but they dont become a problem they move on.....normally the house and then I hear it from my better half its kinda funny when we are scratching and the dogs arnt.....lol

But I truely believe that they are passing through they never are around longer than a few days then my wife stops grumbling and its buisness as uusual at the hypa house.


I have been working on dogs here locally for years im no expert either but have seen ivomec clear up the worst looking dogs . Usually the owner needs cleaning up b4 the dog.

The one I do know is once your dog is well into infestation of heart worms you ARE sending it to the grave when administrating ivomectin and that normally happens when someone acquires a dog from someone who didnt start the dog on a regimen early in life.


Thanks

Chris burner

[MrsLouisianaHogDog]

Also....that one study....it said they had to inject 150lb worth sub-q in the dogs for it to kill brown dog ticks in a 3-4 day period. I certainly would not be fond of the idea of injecting that high of a volume of Ivomec sub-q into any of my dogs.  

Here's a small tid-bit of info on side-effects I stunbles across....( direct link: http://www.ehow.com/about_6566793_ivermectin-ticks.html )

Side Effects

Side effects may be one reason why ivermectin is not commonly used for ticks. Doses for heartworm prevention are 50 times lower than doses needed for the prevention of other parasites. Low or no side effects occur at these low doses, but problems may arise with higher doses. According to Washington State University's College of Veterinary Medicine, "Some dog breeds are more sensitive to certain drugs than other breeds. Collies and related breeds, for instance, can have adverse reactions to drugs such as ivermectin."

I have found NOTHING even on some really informative educational sites supporting the fact that Ivomec is effective against fleas. If anyone else does, please share. I only found the info Mr. Whitten already posted in regards to the brown dog ticks.

All in all, I will not be dosing my dogs that high, sub-q, nor orally on a once a month basis. I'd rather just go with remedies I know are much safer when need be.

[Reuben]

I have given my dogs 1.5 cc's of ivomec 3 times in 15 days and all were fine and free of ear mites within 2 weeks...gave it to them just under the skin...this med might be toxic but usually takes quite a bit to actually become toxic...but I do remember all the talk about the collie breeds...

[halfbreed]

   no I don't use the high dose of ivomect either just posting the tick info . I use the standard dose for my heartworm prevention and I use permethrin 10% for fleas and ticks  works great and much cheaper  lol .

[ar.hogdog]

Ivomec does not repel or keep ticks from attaching to dogs. There are no properties in Ivomec that work against ticks, nor fleas for that matter. Years and years, myself and others around me have given Ivomec once a month as a heartworm preventative, but it does not repel or kill fleas and ticks, that I know for sure. I've heard a couple folks here and there that are under that misconception, but it is indeed a falsehood.

x2

[halfbreed]

  I guess them scientist were wrong ?